Natural Products Inhibiting Key Zika Virus Replication Proteins
Invited Lecture (IL)
Biotransformation and Biotechnology of Natural Products
Date and time:
14:20 to 15:00 on 11/11/2021
Dra Melina Mottin has been working on the OpenZika Project since 2016. The main goal of the project is to prioritize new compounds against Zika virus proteins that act in the viral replication process, through computational strategies. The OpenZika Project is a global research collaboration with Word Community Grid of IBM, led by Dr. Carolina Horta Andrade at the Federal University of Goiás. Dra Melina will talk about some natural products prioritized by target-based virtual screening and machine learning modelling. The compounds were validated through enzymatic and cellular assays and some hits inhibit ZIKV protease, helicase and polymerase proteins.
University of Brasilia
Dr. Melina Mottin received her PhD in Physical Chemistry at University of Campinas (Unicamp) (2015). She is an expert in molecular dynamics simulations, molecular docking and Machine Learning modelling. She is a Pos-doc fellow in the Laboratório de Interação Patógeno-Hospedeiro (UnB) developing the project "Artificial intelligence, molecular modeling and experimental evaluation to discover new trypanocidal agents that inhibit Trypanosoma cruzi oligopeptidases". She also is a Research Associate in the LabMol (UFG) and has been working on the OpenZika Project to prioritize new compounds able to inhibit Zika and Dengue proteins, through the integration of several computational strategies.
8th BCNP/ XXXIV RESEM
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