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Secondary Metabolites And Their Biological Activities From Marine-derived Fungi From Tropical Waters

Type:

Invited Lecture (IL)

Category:

Biosynthesis and Molecular Biology of Natural Products

Place:

Online

Date and time:

13:40 to 14:20 on 11/11/2021

In the past years, there has been an increasing interest on marine-derived fungi as a target source of bioactive marine natural products because many consider them among the world’s greatest untapped resources for new biodiversity as well as chemodiversity. Additionally, through established culture methods, they are able to produce quantity of compounds needed for medicinal chemistry development, clinical trials and even marketing.

In our ongoing project on the search for bioactive compounds from marine-derived fungi from the tropical seas, we have focused mainly on marine-derived fungi of the genera Neosartorya, Talaromyces, Eurotium, Aspergillus, Penicillium, Acremonium and Sporidesmium, isolated from sponges, soft coral, sea-fan, macro-algae, and mangrove which were collected from the Gulf of Thailand and Andaman Sea. Several new secondary metabolites, including prenylated indole derivatives, quinazolinone and pyrazinoquinazolinone containing indole derivatives, polyketides, isocoumarins, anthraquinones, meroditerpenes and cyclic peptides have been isolated from these fungi.

The structures of the compounds were elucidated by extensive analysis of 1D and 2D NMR while the absolute configurations of their stereogenic carbons were established by X-ray analysis, comparison of the calculated and experimental ECD spectra as well as chiral HPLC. Some of the isolated compounds displayed interesting in vitro biological activities such as antibacterial, antibiofilm, anti-obesity, anticholinesterase, and cytotoxicity against a panel of human cancer cell lines.

Speaker


ANAKE KIJJOA

Dr. ANAKE KIJJOA

Universidade do Porto

Dr Kijjoa is a Professor and Head of Chemistry Department of the Biomedical Sciences Institute Abel Salazar and also a Head of the “Chemistry and Biological Activities of Marine Natural Products Research group” of the Interdisciplinary Centre of Marine and Environmental Research (CIIMAR) of the University of Porto, Portugal. He received his BSc in Pharmacy (Magna cum laude) from Chulalongkorn University, Bangkok, Thailand, and PhD in Organic Chemistry from São Paulo University, Brazil in 1980. He was a post-doctoral researcher at the Institüt de Pharmazeutische Biologie, University of Heidelberg, Germany and at the Department of Chemistry, the Florida State University at Tallahassee, Florida, USA, under a supervision of Prof. Werner Herz. He was awarded Honorary Doctorate from three Universities in Thailand in 2008, 2009 and 2018. He was a chairman of the 6th European Conference on Marine Natural Products (ECMNP) in 2009, and member of International Advisory Board of several ECMNPs. His research interest focuses on isolation, structure elucidation and biological activity evaluation of Natural Products from terrestrial and marine organisms. He has supervised several Master’s and PhD’s of both Portuguese and foreign students as well as post-doctoral fellows. He is currently an Associate Editor of Marine Drugs and member of the Editorial Board of various scientific journals. He is a coauthor of more than 180 original research papers and several book chapters. He was invited as keynote speakers to give plenary lectures in various international conferences.