Natural products as an inspiration for ovarian cancer therapies

: Natural products have inspired many therapies, including a number of those used to treat cancer. The seminar will focus on a class of compounds called phyllanthusmins, which were originally isolated from Phyllanthus poilanei Beille in Vietnam.  Phyllanthusmins will be discussed as late stage autophagy inhibitors in ovarian cancer. The studies will cover strategies to define the biological target and mechanism of action for this interesting set of compounds.