Computational Omics Analysis Of Biosynthetic Diversity: From Natural Product Discovery To Microbiome Ecology
Invited Lecture (IL)
Manufacturing and Quality Control of Herbal Drugs and Essential Oils
Date and time:
13:00 to 13:40 on 11/10/2021
Plants, fungi and bacteria produce a wealth of specialized metabolites, wich are of great importance from both ecological and clinical perspectives. Due to the accelerated accumulation of omics data, computacional methods have become more and more important to identify these molecules and to assess their biological activities. Here, I will highlith the work performed in my research group on using these approaches to accelerate natural product discovery, as well as to study microbe-microbe and host-microbe interactions in human, plant and animal microbiomes. Specifically, I will discuss the use of sequence similarity networking approaches to investigate biosynthetic diversity across large numbers of genomes, and integrative genome/metabolome mining to link gene clusters to molecules.
Wageningen University & Research
MARNIX H. MEDEMA
Marnix Medema is an Assistant Professor of Bioinformatics at Wageningen University, The Netherlands. He obtained a Biology BSc (Radboud University Nijmegen, 2006) and a Biomolecular Sciences MSc (University of Groningen, 2008). In 2013, he completed his PhD with Eriko Takano and Rainer Breitling in Groningen; during this period, he was also a visiting fellow with Michael Fischbach at the University of California, San Francisco. Following a postdoc at the Max Planck Institute for Marine Microbiology in Bremen, Germany, he joined Wageningen University in 2015. There, his group develops computational methodologies to unravel natural product biosynthesis using omics data, and applies these methods to the study of molecular interactions in microbiomes. He built and co-coordinates the development of the antiSMASH software for the identification of biosynthetic gene clusters, along with several other algorithms for omics-based natural product discovery. Medema is a recipient of NWO Rubicon and Veni fellowships and an ERC Starting Grant, and received several prizes for his work, including the NBIC Young Investigator Award. He is editorial board member of Natural Product Reports, mSystems and FEMS Microbes, senior editor of ISME Communications, member of the scientific advisory board of Hexagon Bio, and co-founder of Design Pharmaceuticals.
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