Accelerating Discovery Of Drug Leads For Type 2 Diabetes By Advanced Bioactivity-correlating Techniques

Type:

Opening Conference

Category:

Conference

Place:

Online

Date and time:

14:00 to 15:00 on 11/09/2021

To accelerate the search for new bioactive natural products with potential as drug leads to manage type 2 diabetes, there is a need for advanced technologies that allow pinpointing, isolation, and structure elucidation of individual constituents responsible for the bioactivity of crude extracts. In this lecture, the use of advanced bioactivity-correlating technologies like ligand fishing, bioactivity-correlated metabolomics, and high-resolution inhibition profiling coupled with high-performance liquid chromatography-photodiode array-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance, i.e., HPLC-PDA-HRMS-SPE-NMR, will be presented.

Speaker

DAN STAERK

University of Copenhagen

Dan Staerk obtained his Master of Science in Chemistry and Molecular biology/Biochemistry from University of Southern Denmark in 1997 and his PhD in Pharmaceutical Sciences from the Danish University of Pharmaceutical Sciences in 2000, where he specialized in natural products research. After a period as Assistant Professor (2000-2003) and Associate Professor (2003-2008) at Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen (UCPH), he was appointed Professor at Faculty of Life Sciences, UCPH. Since 2012 he has been Professor in Natural Products Research at Department of Drug Design and Pharmacology, UCPH, where he is also heading Copenhagen Small Molecule NMR Centre. Professor Staerk's main research interest is development and application of advanced analytical techniques for accelerated analysis of bioactive natural products in complex extracts of plants and microorganisms. This includes technologies like ligand-fishing, high-resolution inhibition profiling, hyphenated HPLC-PDA-HRMS-SPE-NMR, and metabolomics. Special interest is on bioactive natural products and peptides for treatment of metabolic diseases, but his interests also include antimicrobial compounds and efflux pump inhibitors.

Chair

LUCILIA KATO

Federal University of Goiás

8th BCNP/ XXXIV RESEM Galoá

8th Brazilian Conference on Natural Product/ XXXIV RESEM uses Galoá to painless manage and increase the impact of the event.

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